Posts Tagged: Technology

Researchers developed a gene-editing technology that reduces ‘bad’ cholesterol

In a trial run by Verve Therapeutics, a Cambridge–based biotech company, researchers discovered that a single infusion of a gene-editing treatment called VERVE-101 was able to reduce cholesterol levels in patients. This treatment was tested in individuals with hereditary conditions that made them susceptible to developing clogged arteries and heart attacks. Scientists were able to use CRISPR editing techniques to tweak liver gene cells. The researchers “turned off” a cholesterol-raising gene called PCSK9, which is found in the liver, in order to lower LDL-C — sometimes called “bad” cholesterol — which causes plaque to build up in arteries in the first place.

PCSK9 was lowered by as much as 84 percent in the cohorts that received higher infusion rates of the treatment. At those higher treatment doses, Verve scientists said that the reduction of those LDL-C-related proteins lasted 2.5 years in previous studies on primates.

VERVE-101 explained visual.
Verve Therapeutics

From a clinical standpoint, this gene editing therapy has the potential to disrupt the current standard treatment for high cholesterol. The current go-to’s include prescription statins and PCSK9 inhibitors, but they require strict adherence and can have bad side effects like muscle pain and memory loss.

CRISPR, while seemingly miraculous, is a long way from replacing daily medications though. According to Nature, two of the 10 participants in the study suffered from a “cardiovascular event” that coincided with the infusion. Verve says one was not related to the treatment at all and the second was “potentially related to treatment due to proximity to dosing.” The use of a gene-editing technology will always carry some risk because the edits could occur elsewhere in the genome.

Before a single infusion therapy for high cholesterol can reach consumers, the FDA mandates that the treatment will need to be studied for up to 15 years. Verve recently received FDA clearance for an Investigational New Drug Application for VERVE-101, meaning that the company can begin to conduct trials in the US. The current trials in New Zealand and the United Kingdom will look for willing clinical trial participants to expand the study.

This article originally appeared on Engadget at https://www.engadget.com/researchers-developed-a-gene-editing-technology-that-reduces-bad-cholesterol-170040293.html?src=rss

Engadget is a web magazine with obsessive daily coverage of everything new in gadgets and consumer electronics

[Deal] Save 20% on Ugreen’s cute Robot 3-Port 65W Fast Charger with GaN technology

When it comes to chargers you don’t tend to get much in the way of design other than the likelihood of a square or rectangular shape. Ugreen is here with a different take on things with its 3-Port Robot GaN Fast Charger which, as the name suggests, looks like a robot. Besides offering 65W fast-charging, […]

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The Onyx BOOX Tab X is now on sale with an A4-ePaper display, Super Refresh Technology, and the Play Store

Onyx Boox has unveiled its new A4-sized Tab X ePaper Tablet PC which merges the capabilities of an Android tablet with an e-reader. Complete with the Play Store, Tab X is designed for reading. taking notes with the included stylus and boasts a dedicated GPU which makes the refresh experience ultra-smooth and responsive. The first […]

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New 3D smartphone technology could change photography, experts say

Researchers at Stanford University have created a novel approach that allows standard image sensors to see light in three dimensions.
Mobile | Digital Trends

Realme’s upcoming GT Neo 3 will feature an insane 150W fast-charging technology

MWC 2022 has kicked off, and Realme has just held its keynote session where it unveiled its new 150W fast-charging technology that can charge a 5,000mAh battery to 50% in just 5 minutes, which is insane when you think of it. The new UltraDart Charging Architecture will make its debut on the upcoming GT Neo […]

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US Department of Energy wants to dramatically reduce the cost of carbon capture technology

The US Department of Energy wants to accelerate the development of carbon capture technology. On Friday, the agency announced a program called Carbon Negative Shot. Part of its Energy Earthshots initiative, the goal here is to foster the development of carbon capture technology that can sequester CO2 at a cost of less than $ 100 per ton, and can be deployed at the gigaton scale. To put that in perspective, that much carbon is equivalent to the annual emissions of approximately 250 million cars.

“By slashing the costs and accelerating the deployment of carbon dioxide removal — a crucial clean energy technology — we can take massive amounts of carbon pollution directly from the air and combat the climate crisis,” said Secretary of Energy Jennifer M. Granholm. “With our Carbon Negative Shot, we can help remove the greenhouse gases already warming our planet and affecting our health — positioning America as a net-zero leader and creating good-paying jobs for a transitioning clean energy workforce.”

If it wasn’t clear already, the Energy Department has set an ambitious target. In September, Orca, the largest direct carbon capture facility ever, opened in Iceland. The plant will capture 4,000 tons of CO2 per year at a cost of about $ 600 per ton for bulk purchases. Chimeworks, the company that operates Orca, aims to reduce the cost to $ 300 or less per ton by 2030. That’s a long way away from the Energy Department’s goal of less than $ 100 per ton, but sustained and substantial support and investment from the government is exactly what could make that happen.

Engadget is a web magazine with obsessive daily coverage of everything new in gadgets and consumer electronics

COVIDWISE COVID-19 exposure tracking app released by Virginia Department of Health, utilizing Apple and Google’s contact tracing technology

COVIDWISE, the first US COVID-19 exposure tracking app that fully utilizes Apple and Google’s contact tracking technology, has just released by the Virginia Department of Health. The app places anonymity and privacy high on the agenda and is free to download. Virginia is the first US state to release an app that fully uses the […]

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Samsung working on new OLED technology called HOP for the Galaxy Note 20

The Samsung Galaxy Note family has traditionally received the very latest and best of Samsung’s technology, and the South Korean conglomerate is said to be preparing a cutting-edge OLED panel for the Galaxy Note 20. This new technology is called HOP, an abbreviation of Hybrid-oxide and Polycrystalline silicon, and could reduce display power consumption by […]

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Honda will build two EVs based on GM battery technology

Honda will launch two new EVs for model year 2024 in the US and Canada, and they'll both be based on GM's EV platform. According to GM EVP Doug Parks, the automakers have teamed up to achieve an "all-electric future" and to deliver…
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[TA Deals] Save 92% on the Microsoft Technology Associate mastery bundle

If you’re ready to take a deep dive and get more familiar with some of Microsoft’s security and networking fundamentals, we’ve got a bundle for you. The Microsoft Technology Associate mastery bundle includes three extremely comprehensive courses. If you’re trying to start up a career using Microsoft tech, these classes will help you ace any […]

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PAX Labs CEO on how technology will demystify cannabis

PAX makes some of the most popular cannabis vaporizers around. By fusing technology, with innovative software, the company hopes to take the mystery out of getting high. But, there are problems. Many people don't know where to start, it's still i…
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NASA will publicly test quiet supersonic technology in November

You won't have to wonder what NASA's quiet supersonic technology sounds like in person — if you live in the right part of Texas, that is. The administration plans to conduct a series of public tests around the coastal city of Galveston in November….
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Video referee technology influences its first World Cup goal

When FIFA greenlit the use of video assistant referees at the 2018 World Cup, there was one overriding question: how long would it take before the technology shaped an important call? Not long at all, apparently. Two days into the group stage, offi…
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Technology is failing to create transparent supply chains

During the early days of globalization, it was relatively easy for corporations to either hide, or be ignorant of, human rights and environmental atrocities committed along their supply chain. Factories and producers were shifting manufacturing or so…
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Airbnb is buying a scam-fighting background check technology

Airbnb is getting more serious when it comes to keeping fraudulent listings and shady renters off the website. According to Bloomberg, the short-term rental platform is buying Trooly Inc., a startup specializing in background checks to fight off scam…
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Qualcomm amps up charging technology with new Quick Charge 4+ capabilities

Earlier this year in conjunction with the release of the Snapdragon 835 processor, Qualcomm also announced they were going to introduce a new Quick Charge 4 scheme for when devices do need to be recharged. In some of our tests, like with the Samsung Galaxy S8+ that features the Snapdragon 835, we found power management […]

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Nuclear warfare and the technology of peace

The atom captivated the world in 1939. Since the discovery of the neutron in the early 1930s, the international scientific community had been racing to unlock new elements and further understand the immense power trapped inside the smallest, most ba…
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5 of our favorite mad gadgets from the London Wearable Technology Show

We spent time on the show floor at the recent London Wearable Technology show, finding the most unusual, fun, different, and downright mad new gadgets on display. Here are our five favorites from the show.

The post 5 of our favorite mad gadgets from the London Wearable Technology Show appeared first on Digital Trends.

Wearables–Digital Trends

Nick Offerman offers a more intimate technology when text messages don’t cut it

Actor and humorist Nick Offerman chatted with Digital Trends’ Greg Nibler and Rick Stella about new technology he’s revealing at CES 2017. There are times when a text message just doesn’t convey the emotional impact of another technology, he said.

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Cool Tech–Digital Trends

A 60 fps, 4K action camera could be coming in 2017 from Yi Technology

In 2017, a 4K, 60 fps action camera could hit the market and challenger-brand Yi Technology aims to make the first one. The company teased its new cameras during a pre-CES announcement over the weekend.

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Cool Tech–Digital Trends

How AMOLED technology works

It’s no doubt that you’ve heard the words “Super AMOLED” or “AMOLED” before. Not only is it a technology, but the words are oft thrown about in marketing to catch your attention, too. But, many of us don’t know what AMOLED technologies are and how they affect our smartphones. There’s quite a lot too them […]

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Geohot open-sources his semi-autonomous car technology

George "Geohot" Hotz's semi-autonomous driving add-on, Comma One, didn't work out as planned. However, that doesn't mean the underlying technology will never see the light of day — far from it. The Comma.ai team has published the source code for b…
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Today we carry technology. Tomorrow we’ll wear it

No longer just a means for protecting us from the elements, tomorrow’s clothing will be stronger, lighter, more comfortable, custom fitted to us, and even smart enough to interact with our gadgets.

The post Today we carry technology. Tomorrow we’ll wear it appeared first on Digital Trends.

Wearables–Digital Trends

Seven easy ways to track your sleep habits with technology

There are a handful of different ways you can leverage today’s tech to get a better night’s sleep, so we rounded up seven of the best ways to do so. Read on to get the lowdown on the best sleep-tracking tech around.

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Wearables–Digital Trends

Smart solar kiosks: Poverty reduction through machine-to-machine technology

African Renewable Energy Distributor uses solar phone-charging carts in Rwanda to provide jobs and help phone users with no access to electricity. The micro-franchise is available free to women and disabled men.

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Cool Tech–Digital Trends

Fleksy’s team is going to Pinterest, but its technology is going public

It’s not very common for a team to be acquired but not its technology, and that’s exactly what happened today between a photo sharing service and a keyboard replacement. Pinterest has announced it is bringing in the team behind Fleksy, which is a very popular keyboard replacement that’s used by millions of people on Android […]

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New smart gun technology may help with gun safety in the US

Following President Obama’s executive action announcement this past Tuesday, renewed attention is being paid to the notion of “smart guns,” with newly developed technology taking center stage.

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Cool Tech»Digital Trends

Ralph Lauren’s new smart Polo shirts combine fashion and technology

With Ralph Lauren’s introduction of their new “smart” PoloTech shirt, high-tech fashion is now synonymous with high-fashion technology. For a cool $ 295, you can be the proud owner of one of these luxury items.

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Wearables»Digital Trends

Best Wearable Technology For Students

Heading back to school and want a new piece of wearable tech? There’s a lot of choice out there, so to help out, here are our five wearable picks for 2015, based on functionality, style, and price.

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Wearables»Digital Trends